Rob Stein

Rob Stein is a correspondent and senior editor on NPR's science desk.

An award-winning science journalist with more than 30 years of experience, Stein mostly covers health and medicine. He tends to focus on stories that illustrate the intersection of science, health, politics, social trends, ethics, and federal science policy. He tracks genetics, stem cells, cancer research, women's health issues, and other science, medical, and health policy news.

Before NPR, Stein worked at The Washington Post for 16 years, first as the newspaper's science editor and then as a national health reporter. Earlier in his career, Stein spent about four years as an editor at NPR's science desk. Before that, he was a science reporter for United Press International (UPI) in Boston and the science editor of the international wire service in Washington.

Stein's work has been honored by many organizations, including the National Academy of Sciences, the American Association for the Advancement of Science, the American Association for Cancer Research, and the Association of Health Care Journalists. He was twice part of NPR teams that won Peabody Awards.

Stein frequently represents NPR, speaking at universities, international meetings and other venues, including the University of Cambridge in Britain, the World Conference of Science Journalists in South Korea, and the Aspen Institute in Washington, DC.

Stein is a graduate of the University of Massachusetts, Amherst. He completed a journalism fellowship at the Harvard School of Public Health, a program in science and religion at the University of Cambridge, and a summer science writer's workshop at the Marine Biological Laboratory in Woods Hole, Mass.

There's been a lot of excitement lately that the powerful gene-editing technique CRISPR could offer a new way to treat health problems ranging from cancer to blindness.

But there hasn't been much direct scientific evidence in actual patients about whether it might work or would be safe — until now.

Chinese scientists have published the first report in a scientific journal of an attempt to use CRISPR-edited cells in a patient--a 27-year-old man who is HIV-positive.

Scientists have invented a device that can quickly produce large numbers of living entities that resemble very primitive human embryos.

Researchers welcomed the development, described Wednesday in the journal Nature, as an important advance for studying the earliest days of human embryonic development. But it also raises questions about where to draw the line in manufacturing "synthetic" human life.

Copyright 2019 NPR. To see more, visit https://www.npr.org.

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First it was human embryos. Now scientists are trying to develop another way to modify human DNA that can be passed on to future generations, NPR has learned.

Reproductive biologists at Weill Cornell Medicine in New York City are attempting to use the powerful gene-editing technique called CRISPR to alter genes in human sperm. NPR got exclusive access to watch the controversial experiments underway.

Updated at 4:05 p.m. ET

For the first time, doctors in the U.S. have used the powerful gene-editing technique CRISPR to try to treat a patient with a genetic disorder.

Scientists have created living entities that resemble very primitive human embryos, the most advanced example of these structures yet created in a lab.

The researchers hope these creations, made from human embryonic stem cells, will provide crucial new insights into human development and lead to new ways to treat infertility and prevent miscarriages, birth defects and many diseases. The researchers say this is the first time scientists have created living models of human embryos with three-dimensional structures.

A Russian scientist says he wants to create more genetically modified babies, flouting international objections that such a step would be premature, unethical and irresponsible.

Denis Rebrikov, a molecular biologist who heads a gene-editing lab at the Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology in Moscow, claims he has developed a safe — and therefore acceptable — way to create gene-edited babies.

A congressional committee voted Tuesday to continue a federal ban on creating genetically modified babies in the United States.

The House Appropriations Committee voted to retain the ban after the prohibition had been lifted last month by a subcommittee. The vote was part of debate over routine funding legislation for the Food and Drug Administration.

There are new concerns about the world's first genetically modified babies.

It appears that the genetic variation a Chinese scientist was trying to re-create when he edited twin girls' DNA may be more harmful than helpful to health overall, according to a study published Monday. The study, in Nature Medicine, involves the DNA of more than 400,000 people.

The federal Food and Drug Administration has approved a gene therapy for a rare childhood disorder that is now the most expensive drug on the market. It costs $2.125 million per patient.

But for those patients lucky enough to get it, it appears it can save their lives with a one-time treatment.

Three-year-old Donovan Weisgarber is one of those patients. When he was born he seemed perfectly healthy. But within weeks, it became clear something was terribly wrong.

Alphonso Evans rolls his wheelchair into a weight machine in the gym at the Charlie Norwood VA Medical Center in Augusta, Ga.

"I'm not so much worried about dying from a heart attack or diabetes, because I'm active. I know what to do to work against it: watch what I eat, exercise," Evans says. "But what do I do about an infection? Or fighting off a bacteria — something inside me that I don't see until it's too late?"

For the first time, scientists have used genetically modified viruses to treat a patient fighting an antibiotic-resistant infection.

Isabelle Carnell-Holdaway, 17, began the experimental treatment after doctors lost all hope. She was struggling with a life-threatening infection after a lung transplant. With the new treatment, she has not been completely cured. But the Faversham, England, teenager has recovered so much that she has resumed a near-normal life.

The powerful gene-editing technique called CRISPR has been in the news a lot. And not all the news has been good: A Chinese scientist stunned the world last year when he announced he had used CRISPR to create genetically modified babies.

A group of prominent scientists and bioethicists is calling for a global moratorium on any new attempts to bring gene-edited babies into the world.

"We call for a global moratorium on all clinical uses of human germline editing — that is, changing heritable DNA (in sperm, eggs or embryos) to make genetically modified children," the 18 scientists and bioethicists from seven countries write in an article published Wednesday by the journal Nature.

Instead of eating a typical breakfast every day, Jonah Reeder gulps down a special protein shake.

"The nutrients in it like to sit at the bottom, so I usually have to shake it up and get all the nutrients from the protein and everything," says Reeder, 21, of Farmington, Utah, as he shakes a big plastic bottle.

In February, scientists started releasing genetically engineered mosquitoes in a high-security laboratory in Terni, Italy.

NPR was the only news organization allowed into the lab to witness the first releases. Correspondent Rob Stein reported on the start of the experiment: "Scientists Release Controversial Genetically Modified Mosquitoes In High-Security Lab."

Scientists have launched a major new phase in the testing of a controversial genetically modified organism: a mosquito designed to quickly spread a genetic mutation lethal to its own species, NPR has learned.

For the first time, researchers have begun large-scale releases of the engineered insects, into a high-security laboratory in Terni, Italy.

"This will really be a breakthrough experiment," says Ruth Mueller, an entomologist who runs the lab. "It's a historic moment."

A scientist in New York is conducting experiments designed to modify DNA in human embryos as a step toward someday preventing inherited diseases, NPR has learned.

For now, the work is confined to a laboratory. But the research, if successful, would mark another step toward turning CRISPR, a powerful form of gene editing, into a tool for medical treatment.

There's yet more disturbing news about kids vaping nicotine.

Vaping jumped dramatically again among high school students between 2017 and 2018.

In fact, it was the biggest one-year spike of any kind in the 44 years the Monitoring the Future survey has been tracking substance abuse by young people.

Three of the most influential scientific organizations in the world are calling for an urgent international effort to prevent scientists from creating any more gene-edited babies without proper approval and supervision.

Global standards are needed quickly to ensure gene-editing of human embryos moves ahead safely and ethically, according to the presidents of the U.S. National Academy of Medicine, U.S. National Academy of Sciences and the Chinese Academy of Sciences.

Ever since a Chinese scientist rocked the world by claiming he had created gene-edited twin girls, international outrage has only intensified.

A Chinese scientist's claims that he created the world's first gene-edited babies is a "deeply disturbing" and "irresponsible" violation of international scientific norms, according to a formal conclusion issued Thursday by organizers of the Second International Summit on Human Genome Editing in Hong Kong.

But the summit rejected calls for a blanket moratorium on such research, saying that the work could eventually lead to new ways to prevent a long list of serious genetic diseases.

The Food and Drug Administration announced Thursday that it will seek a ban on the sale of menthol-flavored cigarettes.

The announcement came as the agency officially released a detailed plan to also restrict the sale of flavored electronic cigarettes. It also wants to ban flavored cigars.

Danielle Vukadinovich is sitting up in a hospital bed at the Inova Women's Hospital in Falls Church, Va., waiting to give birth.

"I feel good, I'm excited!" says Vukadinovich, 35, of Annandale, Va., "Nervous, but good!"

Vukadinovich is getting a cesarean section today. It's the second time for her — she underwent the surgical procedure 19 months ago when her twins were born.

Police in California made headlines this spring when they charged a former police officer with being the Golden State Killer, a man who allegedly committed a series of notorious rapes and murders in the 1970s and '80s.

Authorities revealed they used DNA from a publicly available genealogy website to crack the case.

Since then, police around the country have started doing the same sort of thing to solve other cold cases.

For the first time, scientists have demonstrated that a controversial new kind of genetic engineering can rapidly spread a self-destructive genetic modification through a complex species.

Copyright 2018 NPR. To see more, visit http://www.npr.org/.

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A big, new study found the risks of taking a low-dose aspirin every day outweighs the benefits. This is for otherwise healthy older people. What about the rest of us? NPR health correspondent Rob Stein joins us now to talk about it. Welcome to the studio, Rob.

Many healthy Americans take a baby aspirin every day to reduce their risk of having a heart attack, getting cancer and even possibly dementia. But is it really a good idea?

Results released Sunday from a major study of low-dose aspirin contain a disappointing answer for older, otherwise healthy people.

It's early in the morning and 20-year-old Aaron Reid looks like he's sleepwalking.

His head nods forward and he shuffles a bit as he heads toward the pediatric clinic at the National Institutes of Health Clinical Center.

Reid, who has been fighting leukemia since he was 9-years old, is experiencing intense pain.

He can't say much at the moment, so his mother, Tracie Glascox, speaks for him. "He's been complaining of pain in his ankles, his knees and his arms," she tells the nurse.

The Food and Drug Administration announced a set of major new enforcement actions Wednesday aimed at reducing the sales and marketing of electronic cigarettes to teenagers.

Saying vaping among teenagers has reached "an epidemic proportion," the agency said it was taking a "series of critical and historic" measures to curb the alarming trends.

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